Understanding Replacement of Animal Research
Replacing Animal Research is a UK-based charity dedicated to replacing the use of animals in medical research. Formerly known as the Fund for the Replacement of Animals in Medical Experiments (FRAME), the organisation has been active for over 50 years. It champions the development and use of human-relevant, non-animal research methods to advance scientific knowledge and improve human health.

Support for Researchers
Replacing Animal Research supports the scientific community by:
- Funding Innovative Research: They provide grants for projects that develop and validate non-animal methodologies, such as organ-on-chip technologies and human tissue or computer-based models.
- Scientific Journal: In partnership with Sage the charity publishes ATLA (Alternatives to Laboratory Animals), a peer-reviewed journal that publishes research on alternative methodologies and 3Rs developments.
- Education and Training: They offer training and resources to help researchers and students learn about how to search for and adopt non-animal methods.
- Support the implementation of replacement to help meet the requirements of current animal research legislation, such as the Replacement Checklist for researchers and research reviewers.
Are you a Peer reviewer? The charity run free webinars for grant reviewers on using the Replacement Checklist to support the assessment of grant applications where animal use is proposed.
You can also sign up to receive regular updates on their work.